Leptin:Adiponectin Ratio and Metabolic Syndrome in the General Japanese Population.
10.3343/kjlm.2011.31.3.162
- Author:
Kazuhiko KOTANI
1
;
Naoki SAKANE
Author Information
1. Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. kazukotani@jichi.ac.jp
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Adipocytokine;
Adiponectin;
Leptin;
Metabolic syndrome
- MeSH:
Adiponectin/*blood;
Adult;
Aged;
Aged, 80 and over;
Biological Markers/blood;
Body Mass Index;
Female;
Humans;
Japan;
Leptin/*blood;
Male;
Metabolic Syndrome X/*blood;
Middle Aged;
ROC Curve
- From:The Korean Journal of Laboratory Medicine
2011;31(3):162-166
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Circulating leptin:adiponectin ratio (L:A) is a potential surrogate marker for cardiometabolic diseases; however, the relationship of the L:A with the occurrence of metabolic syndrome (MetS) has not yet been fully explored in the general Japanese population. METHODS: We enrolled 678 Japanese subjects (208 men and 470 women, mean age: 58.8+/-14.4 [SD] yr; mean body mass index: 23.6+/-3.3 kg/m2) in this study, and determined their MetS status by using the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) recommendations with minor modifications for the Japanese population. Biochemical markers such as leptin and adiponectin present in blood were measured. The statistical analyses performed were gender-based. RESULTS: A in subjects with MetS was significantly higher than that in subjects without MetS, regardless of gender. The L:A also showed a significant and gradual increase corresponding to the increase in the number of components of MetS present in both the genders (trend P<0.01). The cut-off level of the L:A to detect MetS was 0.59 (sensitivity: 0.72, specificity: 0.70) in men and 1.04 (sensitivity: 0.72, specificity: 0.69) in women. CONCLUSIONS: These results suggest that the L:A can serve as a clinically useful marker for detecting MetS characteristics in the general Japanese population. The clinical application of this laboratory index for detecting MetS should be assessed in future studies.
