Risk factors for recurrence amongst high intermediate risk patients with endometrioid adenocarcinoma.
10.3802/jgo.2012.23.4.257
- Author:
Agnes Y BAHNG
1
;
Christina CHU
;
Paul WILEYTO
;
Stephen RUBIN
;
Lilie L LIN
Author Information
1. Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. lin@uphs.upenn.edu
- Publication Type:Original Article
- Keywords:
Chemotherapy;
Endometrial neoplasms;
High intermediate risk;
Radiotherapy
- MeSH:
Carcinoma, Endometrioid;
Endometrial Neoplasms;
Female;
Humans;
Hysterectomy;
Lymph Node Excision;
Neoplasm Metastasis;
Pennsylvania;
Recurrence;
Retrospective Studies;
Risk Factors
- From:Journal of Gynecologic Oncology
2012;23(4):257-264
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To determine risk factors associated with recurrence in patients with high intermediate risk (HIR) endometrioid adenocarcinoma. METHODS: A retrospective analysis of patients with HIR endometrioid adenocarcinoma who underwent hysterectomy, bilateral salpingo-oophorectomy, with or without pelvic/para-aortic lymphadenectomy at the University of Pennsylvania between 1990 and 2009 was performed. RESULTS: A total of 103 women with HIR endometrial cancer were identified. Multivariable analysis revealed that > or =2/3 myometrial invasion (HR, 4.79; p=0.010) and grade 3 disease (HR, 3.04; p=0.045) were independently predictive of distant metastases. The 5-year distant metastases free survival (DMFS) for patients with neither or one of these risk factors was 89%, and the 5-year DMFS for patients with both risk factors was 48% (p<0.001). CONCLUSION: Patients with both grade 3 disease and deep third myometrial invasion have a high risk of distant metastases. Identifying these patients may be important in rationally selecting patients for systemic therapy.
