Acute Thrombosis in Coronary and Renal Arteries after Cisplatin and 5-Fluorouracil Administration.
10.4070/kcj.2004.34.4.410
- Author:
Ok Young PARK
1
;
Myung Ho JEONG
;
Suk CHO
;
Du Sun SHIM
;
Bo Ra YANG
;
Young Joon HONG
;
Seung Hyun LEE
;
Woo Seok PARK
;
Weon KIM
;
Ju Han KIM
;
Young Keun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Center of Chonnam National University Hospital, The Chonnam National University Research Institute of Medical Sciences, Gwang Ju, Korea.
- Publication Type:Case Report
- Keywords:
Myocardial infarction;
Platelets;
Angioplasty
- MeSH:
Abdominal Pain;
Angioplasty;
Chest Pain;
Cisplatin*;
Electrocardiography;
Emergency Service, Hospital;
Fluorouracil*;
Follow-Up Studies;
Humans;
Male;
Middle Aged;
Myocardial Infarction;
Phosphotransferases;
Renal Artery*;
Thorax;
Thrombosis*;
Troponin I;
Troponin T;
Urokinase-Type Plasminogen Activator
- From:Korean Circulation Journal
2004;34(4):410-414
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 55-year old male presented with chest and abdominal pain for four hours. One day prior to admission he had received chemotherapeutic agents comprising 130 mg cisplatin and 5,200 mg 5-Fluorouracil for nasopharyngeal carcinoma. EKG showed ST elevations in the leads II, III and aVF. The levels of cardiac enzymes were elevated [creatine kinase (CK) 1129 U/L, CK-MB 180 U/L, troponin T 1.23 ng/mL and troponin I 23.29 ng/mL]. Urokinase was administered at the emergency room, but the patient's chest pain continued with persistent ST segment elevations. Urgent coronary and renal angiograms revealed thrombotic occlusive lesions in the distal right coronary and right renal arteries. Percutaneous transluminal renal angioplasty using 6.0x20 mm balloon was performed for the renal artery. However, filling defects and distal renal flow were not improved and so Abciximab (ReoPro(r)) was administered. Follow-up coronary and renal angiograms on the fifth hospital day showed no filling defects with good distal flow in both right coronary and renal arteries.
