The Role of the UBC Test in Transitional Cell Carcinomas of the Bladder.
- Author:
Sang Hyeon CHEON
1
;
Jun Hyuk HONG
;
Jim Bum KIM
;
Jin Sook RYU
;
Han Kwon KIM
;
Choung Soo KIM
Author Information
1. Department of Urology, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tumor markers;
Bladder neoplasms;
Transitional cell carcinoma;
Cytokeratin
- MeSH:
Carcinoma, Transitional Cell*;
Cystoscopy;
Diagnosis;
Follow-Up Studies;
Humans;
Keratins;
Recurrence;
Sensitivity and Specificity;
Biomarkers, Tumor;
Urinary Bladder Neoplasms;
Urinary Bladder*;
Urinary Tract Infections;
Urologic Diseases
- From:Korean Journal of Urology
2003;44(1):17-21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the diagnostic performance of a noninvasive bladder cancer test, the urinary bladder cancer (UBC) antigen test, on voided urine samples from patients with active transitional cell carcinomas, on follow-up and controls. MATERIALS AND METHODS: We measured the UBC antigen in the urine from 136 patients with active transitional cell carcinomas of the bladder (group 1), 56 patients with no evidence of tumor recurrence, confirmed by cystoscopy at follow-up (group 2), 60 patients with urinary tract infections (group 3), 52 patients with other genitourinary tract malignancies (group 4) and 74 healthy subjects, free from urological diseases (group 5). RESULTS: The mean UBC antigen concentrations were 75.79, 28.95, 52.90, 16.90 and 7.56micro gram/L, in groups 1 to 5, respectively. Group 2, 4 and 5 showed statistically significant differences in the UBC concentrations compared to group 1 (p=0.03, <0.001 and <0.001, respectively). Sensitivity and specificity were 61.8 and 68.2%, at a threshold value of 9.7micro gram/L, from group 1, compared to groups 2 to 5. As for the tumor grade in group 1, there were significant differences between grade I and II (p<0.001) or between grade I and III (p<0.001), but there were no significant differences according to the T stage. CONCLUSIONS: The UBC test might have a role as a potential tumor marker for the diagnosis of transitional cell carcinomas of the bladder adjunct to cystoscopy.
