Biodegradability of porous Calcium Polyphosphate.
10.5051/jkape.2001.31.3.555
- Author:
Seung Min YANG
1
;
Young Kyoo LEE
;
Eun Young HAN
;
Seok Young KIM
;
Seung Beom KYE
;
Seung Jin LEE
;
Yong Moo LEE
;
Young KU
;
Chong Pyoung CHUNG
;
Soo Boo HAN
;
Sang Mook CHOI
;
In Chul RHYU
Author Information
1. Department of Periodontology, College of Dentistry, Seoul National University, Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Bone Substitutes;
Calcium*;
Ceramics;
Chitosan;
Connective Tissue;
Dogs;
Giant Cells;
Transplants
- From:The Journal of the Korean Academy of Periodontology
2001;31(3):555-564
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study is to evaluate the bioresorbability of Calcium Polyphosphate added with Na2O and chitosan. Though calcium phosphate ceramics meet some of the needs for bone replacement, they have some limitation of unresorbability and fibrous encapsulation without direct bone apposition during bone remodelling. To solve these problem, we developed a new ceramic, calcium polyphosphate(CPP), and report the biologic response to CPP in extraction sites of beagle dog. Porous CPP granules were prepared by condensation of anhydrous Ca(H2PO4)2 to form non-crystalline Ca(PO3)2. CPP granules added with Na2O and chitosan were implanted in extraction sockets and histologic observation were performed at 12 weeks later. Histologic observation at 12 weeks revealed that CPP matrix were mingled with and directly apposed to new bone without any intervention of fibrous connective tissue. CPP granules added with chitosan were well adatped without any adverse tissue reaction and resorbed slowly and spontaneously. CPP granules added with Na2O and chitosan show multinucleated giant cells and osteoblast-like cells around grafted material and newly formed bone. This result revealed that CPP, regardless of its additive component, had a high affinity for bone and had been resorbed slowly. From this results, it was suggested that CPP is promising ceramic as a bone substitute and addition of Na2O and chitosan help biodegradation. In further study , it will be determined which concentration of Na2O help biodegradation and the other additive components increase the degradation rate.
