Refocusing Peroxisome Proliferator Activated Receptor-alpha: A New Insight for Therapeutic Roles in Diabetes.
10.4093/dmj.2013.37.5.326
- Author:
Hannah SEOK
1
;
Bong Soo CHA
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. bscha@yuhs.ac
- Publication Type:Review
- Keywords:
Diabetes;
Diabetes complications;
Fibric acids;
Peroxisome proliferator activated receptor agonists
- MeSH:
Cardiovascular Diseases;
Diabetes Complications;
Fibric Acids;
Homeostasis;
Inflammation;
PPAR alpha*
- From:Diabetes & Metabolism Journal
2013;37(5):326-332
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-alpha (PPAR-alpha) plays a pivotal role in the regulation of lipid homeostasis, fatty acid oxidation, cellular differentiation, and immune response such as inflammation or vascularization related to diabetic complication. This review will re-examine the metabolic role of PPAR-alpha, summarize data from clinical studies on the effect of PPAR-alpha agonist in diabetes, and will discuss the possible therapeutic role of PPAR-alpha activation.
