Pulsatile GnRH therapy in male patients with hypogonadotropic hypogonadism.
- Author:
Se Joong KIM
1
;
Moo Sang LEE
;
Hyung Ki CHOI
;
Ki Hyun PARK
;
Hyun Chul LEE
Author Information
1. Department of Urology, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Pulsatile GNRH therapy;
Hypogonadotropic hypogonadism
- MeSH:
Gonadotropin-Releasing Hormone*;
Humans;
Hypogonadism*;
Hypothalamic Neoplasms;
Infusion Pumps;
Male*;
Spermatogenesis;
Testosterone
- From:Korean Journal of Urology
1991;32(4):637-641
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effects of pulsatile GnRH therapy have been studied for the treatment of different forms of hypogonadotropic hypogonadism, including idiopathic hypogonadotropic hypogonadism and hypogonadism developed as a result of treatment with combination of surgery and irradiation for pituitary or hypothalamic tumor. GnRH was administered subcutaneously in a dose of 10ug every 2 hours with the pulsatile infusion pump. With GnRH therapy, all patients improved secretion of LH, FSH and testosterone. Testicular volumes increased. Spermatogenesis was induced in 4 patients. Pulsatile GnRH therapy is an effective treatment for idiopathic hypogonadotropic hypogonadism and can have a role in hypogonadism previously treated with combination of surgery and irradiation for pituitary or hypothalamic tumor.
