Quality Control of Tungsten-188/Rhenium-188 Generator.
- Author:
Myung Chul LEE
;
June Key CHUNG
;
Dong Soo LEE
;
Jae Min JEONG
;
Young Soo CHANG
- Publication Type:Original Article
- Keywords:
W-188/Re-188 generator;
Quality control;
Radionuclide therapy
- MeSH:
Aluminum;
Hydrogen-Ion Concentration;
Quality Control*
- From:Korean Journal of Nuclear Medicine
1998;32(5):425-432
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: For the purpose of using Re-188 as a therapeutic radionuclide, we performed the quality control of the W-188/Re-188 generation system. MATERIALS AND METHODS: Several quality control tests of the Re-188 eluate from generator were carried out of about 300 days. After elution of Re-188 with normal saline (20 ml), chromatogram and gamma-ray spectrum of Re-188 eluate were obtained. The presence of aluminum which was derived from the elumina bed of the generator was detected by using aluminum ion indicator kit. Re-188 eluate was allowed to decay for several days, and then W-188 breakthrough in the Re-188 eluate was measured by detecting gamma-ray at 227 keV and 290 keV. The pH and the pyrogenicity of the eluate were checked. The Re-188 eluate from the generator was 67.4+/-7.0% of W-188 during 270 days, and it was hightest at third day after previous elution. Radiochemical purity of Re-188 eluate obtained from chromatogram was higher than 99%. Gamma-ray spectrum of Re-188 eluate showed a peak at 155 keV. Aluminum ion and W-188 contamination were not detected. The pH of Re-188 eluate was 3 and the concentration yield was 85%. CONCLUSION: Our experiments and results on quality control tests of Re-188 eluate from W-188/Re-188 generator may be useful for setting W-188/Re-188 generator in hospitals.
