The acute effect of maximal exercise on plasma beta-endorphin levels in fibromyalgia patients.
10.3344/kjp.2016.29.4.249
- Author:
Ali BIDARI
1
;
Banafsheh GHAVIDEL-PARSA
;
Sahar RAJABI
;
Omid SANAEI
;
Mehrangiz TOUTOUNCHI
Author Information
1. Department of Rheumatology, Iran University of Medical Sciences, Tehran, Iran. bidari.a@iums.com
- Publication Type:Original Article
- Keywords:
Beta-endorphin;
Exercise;
Fibromyalgia;
Healthy subjects;
Pain;
Serum
- MeSH:
beta-Endorphin*;
Exercise Test;
Fibromyalgia*;
Healthy Volunteers;
Heart Rate;
Humans;
Plasma*
- From:The Korean Journal of Pain
2016;29(4):249-254
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study aimed to investigate the effect of strenuous exercise on β-endorphine (β-END) level in fibromyalgia (FM) patients compared to healthy subjects. METHODS: We enrolled 30 FM patients and 15 healthy individuals. All study participants underwent a treadmill exercise test using modified Bruce protocol (M.Bruce). The goal of the test was achieving at least 70% of the predicted maximal heart rate (HRMax). The serum levels of β-END were measured before and after the exercise program. Measurements were done while heart rate was at least 70% of its predicted maximum. RESULTS: The mean ± the standard deviation (SD) of exercise duration in the FM and control groups were 24.26 ± 5.29 and 29.06 ± 3.26 minutes, respectively, indicating a shorter time to achieve the goal heart rate in FM patients (P < 0.003). Most FM patients attained 70% HRMax at lower stages (stage 2 and 3) of M.Bruce compared to the control group (70% versus 6.6%, respectively; P < 0.0001). Compared to healthy subjects, FM patients had lower serum β-END levels both in baseline and post-exercise status (Mean ± SD: 122.07 ± 28.56 µg/ml and 246.55 ± 29.57 µg/ml in the control group versus 90.12 ± 20.91 µg/ml and 179.80 ± 28.57 µg/ml in FM patients, respectively; P < 0.001). CONCLUSIONS: We found that FM patients had lower levels of β-END in both basal and post-exercise status. Exercise increased serum the β-END level in both groups but the average increase in β-END in FM patients was significantly lower than in the control group.
