Increased expressions of claudin-1 and claudin-7 in cervical squamous intraepithelial neoplasias and invasive squamous cell carcinomas.
- Author:
Eun Seop SONG
1
;
Byoung Ick LEE
;
Joon Mee KIM
;
Keon Young LEE
;
Kyung Sin AN
;
Seung Mi SUNG
;
Hye Jin KWON
;
Jee Hyun PARK
;
Jee Young HAN
;
Suk Jin CHOI
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Inha University, Incheon, Korea. songsong2000@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Cervical lesion;
Claudin-1;
Claudin-7
- MeSH:
Carcinoma, Squamous Cell*;
Cervical Intraepithelial Neoplasia;
Claudin-1*;
Pathology;
Tight Junctions;
Uterus
- From:Korean Journal of Obstetrics and Gynecology
2006;49(5):1065-1072
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The change of claudin expressions, integral transmembrane proteins for tight junction, might be related to progression of cervical premalignancy or malignancy. The aim of this study was to verify the tendency of expressions of claudin-1 and -7 according to the progression of cervical pathology of uterus. METHODS: There were 162 tissues obtained at AA institute. 25 tissues were normal, 26 were cervical intraepithelial neoplasia (CIN) 1, 30 were CIN2, 44 were CIN3, 25 were microinvasive cervical carcinomas, and 12 were invasive squamous cervical carcinomas (ISCC). H and E and immunohistochemical staining were done. RESULTS: Among normal tissues, 52% showed no expression, 48% weak expressions at claudin-1, and 28% no expression, 56% weak expressions at claudin-7. Among CIN3, 20% showed weak expressions, 41% showed moderate expressions at claudin-1, and 14% weak expressions, 52% moderate expressions at claudin-7. Among ISCC, 42% showed moderate expressions, 50% strong expressions at claudin-1, and 33% moderate expressions, and 33% strong expressions at claudin-7. These data shows the increasing tendency of claudin-1 and claudin-7 expressions according to the severity of lesions (p<0.01). CONCLUSION: The expressions of claudin-1 and claudin-7 were increased more according to the progression of cervical lesions.
