Langerhans Cell Histiocytosis Presenting as a Solitary Nodule.
- Author:
Jong Rok LEE
1
;
Gwang Seong CHOI
;
Sang Wahn KOO
;
Seung Chul LEE
;
Young Keun KIM
Author Information
1. Department of Dermatology, College of Medicine, Inha University, Inchon, Korea. inhadm@chollian.net
- Publication Type:Case Report
- Keywords:
Langerhans cell histiocytosis;
Solitary nodule
- MeSH:
Antibodies;
Child;
Cytoplasm;
Female;
Histiocytosis, Langerhans-Cell*;
Humans
- From:Korean Journal of Dermatology
2001;39(4):459-462
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Langerhans cell histiocytosis, previously called histocytosis X, is a disease of unknown cause characterized by the proliferation of a distinct cell type that is S-100 and CD1a positive and contains cytoplasmic langerhans granules. We report a case of langerhans cell histiocytosis, which a 10-year-old girl presented as a solitary nodule without systemic involvement. Histologic examination of the nodule showed a dense dermal infiltrate of histiocytic cells with bean-shaped nuclei. These cells reacted with antibodies to S-100 and CD1a. Ultrastructural analysis showed Birbeck granules in the cytoplasm of the histiocytic cells. We confirmed langerhans cell histicytosis presenting as a solitary nodule by above findings.
