Hepatic infarction in a pregnant woman with antiphospholipid syndrome and triple antibody positivity: A case report focusing on catastrophic antiphospholipid syndrome.
10.5468/ogs.2016.59.5.397
- Author:
Ji Hye KIM
1
;
Cheonga YEE
;
Jin Yi KUK
;
Suk Joo CHOI
;
Soo Young OH
;
Cheong Rae ROH
;
Jong Hwa KIM
Author Information
1. Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ohsymd@skku.edu
- Publication Type:Case Report
- Keywords:
Antiphospholipid antibodies;
Catastrophic antiphospholipid syndrome;
HELLP syndrome;
Hepatic infarction;
Triple antibody positivity
- MeSH:
Antibodies, Antiphospholipid;
Antiphospholipid Syndrome*;
Cesarean Section;
Female;
HELLP Syndrome;
Humans;
Infarction*;
Liver;
Pregnancy;
Pregnant Women*;
Pulmonary Embolism;
Tachycardia;
Tachypnea;
Venous Thrombosis
- From:Obstetrics & Gynecology Science
2016;59(5):397-402
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pregnant women with antiphospholipid syndrome (APS) carry a high risk of arterial or venous thrombosis. Such thrombotic conditions occur more frequently in patients with triple positivity to antiphospholipid antibodies or with high antibody titers. Hepatic infarction is a rare complication in pregnant women with APS, and it sometimes mimics HELLP syndrome. This report describes a preeclamptic pregnant woman with APS who had high titers of three antiphospholipid antibodies. She experienced severe epigastric pain with elevated liver enzymes; in addition, she had tachycardia and tachypnea. The clinical findings suggested hepatic infarction and pulmonary thromboembolism, a partial manifestation of catastrophic APS. Therefore, she underwent emergent cesarean section at 25+2 weeks of gestation. After the delivery, her laboratory test indicated HELLP-like features, and computed tomography confirmed hepatic infarction and pulmonary micro-thromboembolism. Here, we report a case of a partial manifestation of catastrophic APS in a pregnant woman with triple antibody positivity, including a brief literature review.
