Overexpression of hTERT and c-erbB-2 are correlated in ovarian epithelial cancer.
- Author:
Sokbom KANG
1
;
Noh Hyun PARK
;
Yoo Kyung LEE
;
Jae Weon KIM
;
Yong Sang SONG
;
Soon Beom KANG
;
Hyo Pyo LEE
Author Information
1. Research Institute and Hospital, National Cancer Center, Goyang, Korea. ksb1231@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Ovarian cancer;
Immunohistochemistry;
hTERT peptide;
c-erbB-2 protein
- MeSH:
Antigens, Viral, Tumor;
Carcinogenesis;
Immunohistochemistry;
Ovarian Neoplasms;
Receptor, erbB-2;
Transfection
- From:Korean Journal of Gynecologic Oncology
2006;17(2):142-146
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: It is still unclear how the abnormal hTERT expression is involved in the process of ovarian carcinogenesis. A recent report demonstrated that the introduction of c-erbB-2 could efficiently induce tumorigenicity of cells with the transfection of SV40 large T antigen and hTERT. It is designed to find correlation between overexpression of hTERT and c-erbB-2 in ovarian carcinogenesis. METHODS: Using immunohistochemistry, we tested whether overexpression of hTERT and c-erbB-2 were associated in ovarian cancer. Immunohistochemical staining of hTERT and c-erbB-2 was done in 63 cases of ovarian cancer. Overexpression of hTERT and c-erbB-2 were correlated to clinicopathological variables. RESULTS: Overexpression of hTERT was found in 7 (11.1%) of cases, whereas overexpression of c-erbB2 was founded in 3 (4.8%) of cases. It was found that overexpression of hTERT and c-erbB-2 were significantly correlated (p=0.03). Neither overexpression of hTERT nor that of c-erbB-2 was associated with any of clinicopathological variables, such as stage, grade, and histology. CONCLUSION: Although the significant correlation between hTERT and c-erbB-2 was found, the low frequency of overexpression of hTERT and c-erbB-2 suggests that cooperation of hTERT and c-erbB-2 may be minor mechanism of ovarian carcinogenesis.
