Declining concentrations of dehydroepiandrosterone sulfate and free testosterone with advancing age.
- Author:
Myoung Seok HAN
1
;
Il Jung CHOI
Author Information
1. Department of Obstetrics and Gynecology, Dong-A University School of Medicine, Busan, Korea. hmsobgy@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Dehydroepiandrosterone sulfate;
Testosterone;
Aging
- MeSH:
Aging;
Amenorrhea;
Dehydroepiandrosterone;
Dehydroepiandrosterone Sulfate;
Female;
Hirsutism;
Humans;
Oligomenorrhea;
Radioimmunoassay;
Testosterone
- From:Korean Journal of Obstetrics and Gynecology
2009;52(6):631-635
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging. METHODS:One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or amenorrhea or hirsutism were recruited for measuring serum DHEAS, FT levels by radioimmunoassay. A P-value <0.05 was considered to be significant statistically. RESULTS: The levels of DHEAS were 211.39+/-33.01 microg/dL (twenties, n=10), 127.99+/-11.79 microg/dL (thirties, n=31), 94.30+/-7.49 microg/dL (forties, n=57) and 71.79+/-5.71 microg/dL (over fifties, n=33) respectively (mean+/-SE, P<0.001). The levels of FT were 3.98+/-0.94 pg/ml (twenties, n=10), 3.37+/-0.47 pg/mL (thirties, n=31), 2.68+/-0.30 pg/mL (forties, n=57) and 1.97+/-0.28 pg/mL (fifties, n=33) respectively (mean+/-SE, P=0.030). Mean value declining of DHEAS (r=-0.48865, P<0.0001) was bigger than those of FT (r=-0.29334, P<0.0007). CONCLUSION: Both DHEAS and FT levels decline with age and DHEAS decreases more steeply than FT.
