Comparison of Factors Which Influence the Brachial-Ankle Pulse Wave Velocity in Pre- and Postmenopausal Women.
- Author:
Chan Kyung CHUNG
1
;
Bo Hyon YUN
;
Seok Kyo SEO
;
Kyung Jin LIM
;
Young Eun JEON
;
Hyo In YANG
;
Kyung Eun LEE
;
SiHyun CHO
;
Young Sik CHOI
;
Byung Seok LEE
Author Information
1. Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Arterial stiffness;
Brachial-ankle pulse wave velocity;
Premenopausal women;
Postmenopausal women
- MeSH:
Blood Pressure;
Female;
Gonadal Steroid Hormones;
Health Promotion;
Humans;
Inflammation;
Logistic Models;
Menopause;
Odds Ratio;
Pulse Wave Analysis;
Retrospective Studies;
Vascular Stiffness
- From:The Journal of Korean Society of Menopause
2010;16(2):86-92
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study was to compare the factors which influence the brachial-ankle pulse wave velocity (baPWV) in pre- and post-menopausal women. We also investigated the association of menopause with arterial stiffness measured by baPWV. METHODS: We performed a retrospective review of 241 postmenopausal women who attended the health promotion center for a routine checkup. Simple and multiple regression analyses were performed to determine the parameters influencing baPWV in pre- and postmenopausal women. Multiple logistic regression analysis was performed to identify the independent parameters related to increased of arterial stiffness. RESULTS: Multiple regression analysis showed that diastolic blood pressure (DBP; beta = 0.402, P = 0.009) was identified as an independent determinant for baPWV in premenopausal women, and DBP (beta = 0.329, P = 0.021) and the neutrophil-to-lymphocyte ratio (NLR; beta = 0.210, P = 0.016) were identified as independent determinants for baPWV in postmenopausal women. The odds ratio (95% CI) of menopause for a high baPWV was 2.666 (1.025~6.937). CONCLUSION: The NLR is associated with arterial stiffness in postmenopausal women. Consequently, inflammation is thought to play a crucial role in increased arterial stiffness in postmenopausal women. Menopause is associated with a high baPWV, suggesting that changes in the concentrations of sex hormones during the menopausal transition may influence arterial stiffness in clinically healthy women.
