Production of Recombinant Anti-Cancer Vaccines in Plants.
10.4062/biomolther.2016.126
- Author:
Jeong Hwan LEE
1
;
Kisung KO
Author Information
1. Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea. ksko@cau.ac.kr
- Publication Type:Review
- Keywords:
Cancer;
Vaccine;
Glycosylation;
Plant expression system;
Subunit vaccine;
Recombinant protein
- MeSH:
Biomass;
Bioreactors;
Glycosylation;
Plants;
Recombinant Proteins;
Vaccines*;
Vaccines, Subunit
- From:Biomolecules & Therapeutics
2017;25(4):345-353
- CountryRepublic of Korea
- Language:English
-
Abstract:
Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.
