Application of the QuantiFERON(R)-TB Gold Test in Two Cases of Erythema Induratum of Bazin.
- Author:
Jae Hong JI
1
;
Hwa Young PARK
;
Yoon Hee LEE
;
Hae Jin LEE
;
Eung Ho CHOI
Author Information
1. Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea. choieh@yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Erythema induratum of Bazin;
Interferon-gamma;
Latent tuberculosis infection;
QuantiFERON(R)-TB Gold test
- MeSH:
Diagnostic Tests, Routine;
Erythema;
Erythema Induratum;
Female;
Humans;
Hypersensitivity;
Interferon-gamma;
Latent Tuberculosis;
Leg;
Mycobacterium;
Mycobacterium tuberculosis;
Skin;
T-Lymphocytes;
Thorax;
Tuberculosis;
Tuberculosis, Cutaneous
- From:Korean Journal of Dermatology
2009;47(7):850-854
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Erythema induratum of Bazin is a chronic, nodular subcutaneous eruption usually occurring on the lower legs of young women. Erythema induratum of Bazin hasbeen regarded as a tuberculide, a hypersensitivity response to Mycobacterium tuberculosis. The pathogenesis of erythema induratum of Bazin associated with tuberculosis is still debatable because mycobacteria cannot be cultured from the skin lesions. QuantiFERON(R)-TB Gold test detects INF-gamma released by T cells in response to Mycobacterium tuberculosis-specific antigens, which offers an improved diagnostic test of latent tuberculosis infection. We experienced two cases of erythema induratum of Bazin, which showed normal chest X-ray and negative TB-PCR. However the QuantiFERON(R)-TB Gold test was positive which led us to a diagnosis of latent tuberculosis infection. Both patients were treated with anti-tuberculosis medications, which was followed by successful resolution of the skin lesions. Therefore, we report the application of the QuantiFERON(R)-TB Gold test for the confirmation of latent tuberculosis infection in erythema induratum of Bazin patients.
