The Polymorphisms of PPAR-gamma Coactivator 1alpha Gly482Ser (PGC-1alpha Gly482Ser) are Associated with the Nephropathy of Korean Patients with Type 2 Diabetes Mellitus.
- Author:
Laeik JUNG
1
;
Jungho SUH
;
Mia KIM
;
Kyunghwan CHUNG
;
Ju Young MOON
;
Sangho LEE
;
Taewon LEE
;
Chunkyu LIM
Author Information
1. Department of Nephrology, College of Medicine, Kyung Hee University, Seoul, Korea. rulale@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Diabetic nephropathy;
Polymorphism;
Peroxisome proliferator-activated receptor gamma;
PPAR-gamma coactivator 1alpha
- From:Korean Journal of Nephrology
2006;25(5):753-759
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We investigated the effects of the common polymorphisms in the peroxisome proliferator- activated receptor gamma2 (PPAR-gamma2 Pro12Ala) and in PPAR-gamma coactivator 1alpha (PGC-1alpha Gly482Ser) genes on the association with the nephropathy of Korean patients with type 2 diabetes mellitus. METHODS: A total of 113 patients with type 2 diabetes and 123 patients with diabetic nephropathy were enrolled in this study. The Pro12Ala polymorphism of the PPAR-gamma2 gene and the Gly482Ser polymorphism in the PGC-1alpha gene were determined with the polymerase chain reaction amplification, BstU-I and Msp I enzyme digestion, and gel electrophoresis. RESULTS: The genotype and allelic frequency of PPAR-gamma2 Pro12Ala gene were not different statistically between the diabetic nephropathy and the control. The genotype of PGC-1alpha Gly482Ser in diabetic nephropathy was also not different from those in control. The allelic frequency and carriage rate of Ser allele in PGC-1alpha Gly482Ser were significantly higher in patients with diabetic nephropathy than those in control (respectively, p<0.05). CONCLUSION: The polymorphisms of the PGC-1alpha Gly482Ser gene are significantly associated with the nephropathy in Korean patients with type 2 diabetes mellitus.
