A Case of Collagenofibrotic Glomerulopathy with Characteristic Electron Microscopic and Immunohistochemistry Findings.
- Author:
Chi Weon KIM
1
;
Hyo Sang KIM
;
Ran Hui CHA
;
Sun Moon KIM
;
Kook Hwan OH
;
Kyung Chul MOON
;
Yon Su KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea. yousukim@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Collagenofibroticglomerulopathy;
Type III collagen
- MeSH:
Biopsy
- From:Korean Journal of Nephrology
2006;25(5):823-827
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Collagenofibrotic glomerulopathy is a relatively rare glomerular disease characterized by the accumulation of spiraled frayed collagen fibrils in mesangial and subendothelial areas. Clinically, patients with the disease usually present with moderate proteinuria and edema. They tend to have hypertension and their renal function deteriorates slowly. We report the case of a patient with collagenofibrotic glomerulopathy who also had Takayasus arteritis and presented with hypertension, proteinuria and dyspnea on exertion. Electron microscopy of the renal biopsy revealed massive accumulation of peculiar collagen fibers and immunohistology using monoclonal antibodies to collagen type III revealed positive stain in glomerular tufts.
