Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes.
- Author:
Eun Ah YU
1
;
Chun Nam CHA
;
Eun Kee PARK
;
Chang Yeul YOO
;
Suk KIM
;
Hu Jang LEE
Author Information
1. Tongyeong National Quarantine Station, Ministry of Health & Welfare, Tongyeong 650-110, Korea.
- Publication Type:In Vitro ; Brief Communication
- Keywords:
crude extracts;
medicinal plants;
mice;
Streptococcus pyogenes;
treatment efficacy
- MeSH:
Animals;
Complex Mixtures;
Ethanol*;
Glycyrrhiza uralensis*;
Mice*;
Microbial Sensitivity Tests;
Plants, Medicinal;
Sophora*;
Streptococcus;
Streptococcus pyogenes*;
Survival Rate;
Treatment Outcome
- From:Korean Journal of Veterinary Research
2014;54(3):189-192
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20 microg/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4x MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
