Effect of Improvement in Lower Urinary Tract Symptoms on Sexual Function in Men: Tamsulosin Monotherapy vs. Combination Therapy of Tamsulosin and Solifenacin.
10.4111/kju.2014.55.9.608
- Author:
Kyungtae KO
1
;
Dae Yul YANG
;
Won Ki LEE
;
Sae Woong KIM
;
Du Geon MOON
;
Ki Hak MOON
;
Nam Cheol PARK
;
Jong Kwan PARK
;
Hwan Cheol SON
;
Sung Won LEE
;
Jae Seog HYUN
;
Kwangsung PARK
Author Information
1. Department of Urology, Hallym University College of Medicine, Chuncheon, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Erectile dysfunction;
Lower urinary tract symptoms;
Overactive urinary bladder
- MeSH:
Aged;
Drug Therapy, Combination/methods;
Erectile Dysfunction/*drug therapy/etiology;
Humans;
Lower Urinary Tract Symptoms/complications/*drug therapy;
Male;
Middle Aged;
Quality of Life;
Questionnaires;
Quinuclidines/*administration & dosage;
Rheology;
Sulfonamides/*administration & dosage;
Tetrahydroisoquinolines/*administration & dosage;
Treatment Outcome;
Urological Agents/*administration & dosage
- From:Korean Journal of Urology
2014;55(9):608-614
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate how much the improvement of lower urinary tract symptoms (LUTS) affects sexual function and which storage symptoms or voiding symptoms have the greatest effect on sexual function. MATERIALS AND METHODS: A total of 187 patients were enrolled in this study. Patients were randomly assigned to receive either tamsulosin 0.2 mg (group A) or tamsulosin 0.2 mg and solifenacin 5 mg (group B). At 4 weeks and 12 weeks, the LUTS and sexual function of the patients were evaluated by use of the International Index of Erectile Function-5 (IIEF5), International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS) questionnaire, uroflowmetry, and bladder scan. RESULTS: Both groups A and B showed statistically significant improvements in IPSS, OABSS, and quality of life (QoL). Group A showed improved maximum flow rate, mean flow rate, and residual urine volume by time. Group B did not show an improvement in flow rate or residual urine volume but total voiding volume increased with time. The IIEF5 score was not improved in either group. In group A, the IIEF5 score dropped from 13.66+/-4.97 to 11.93+/-6.14 after 12 weeks (p=0.072). Group B showed a decline in the IIEF5 score from 13.19+/-5.91 to 12.45+/-6.38 (p=0.299). Although group B showed a relatively smaller decrease in the IIEF5 score, the difference between the two groups was not significant (p=0.696). CONCLUSIONS: Tamsulosin monotherapy and combination therapy with solifenacin did not improve erectile function despite improvements in voiding symptoms and QoL. The improvement in storage symptoms did not affect erectile function.
