Reduced Th1 Response with Herpes Simplex Virus Type 1 in Behcet's Disease.
- Author:
Eun Bong LEE
1
;
Kwang Yong KIM
;
Su Yeon KIM
;
Eung Soo HWANG
;
Chung Gyu PARK
;
Chang Yong CHA
;
Yeong Wook SONG
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Behcet's disease;
Herpes simplex virus type 1;
Interferon-gamma
- MeSH:
Herpes Simplex*;
Herpesvirus 1, Human*;
Humans;
Interferon-gamma;
Simplexvirus*;
T-Lymphocyte Subsets;
T-Lymphocytes
- From:The Journal of the Korean Rheumatism Association
2006;13(2):132-139
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the interaction of herpes simplex virus type 1 antigen and T cells in Behcet's disease. METHODS: Intracellular interferon-gamma response of T cells was measured before and after stimulation with herpes simplex virus type 1 in 17 patients with Behcet's disease and 20 healthy controls. The proliferation rate and the changes of CD4+/CD8+ T cell subsets were also measured. RESULTS: In the basal status, the proportions of interferon-gamma producing CD4+ or CD8+ T cells were higher in patients with Behcet's disease than healthy controls. The number of interferon-gamma producing CD4+ or CD8+ T cells in patients with Behcet's disease was significantly decreased after stimulation with herpes simplex virus (mean+/-SD, 14.6+/-6.4 % vs 10.0+/-4.7%, p=0.0052 for CD4+ T cells; 29.5+/-14.2% vs 21.2+/-11.8%, p=0.045 for CD8+ T cells), while it did not change in healthy controls (11.5+/-7.4% vs 11.2+/-6.3%, p=0.88 for CD4+ T cells; 19.8+/-15.2 vs 20.7+/-10.8, p=0.84 for CD8+ T cells). There was no difference in the proliferation rate or CD4+/CD8+ subset changes between patients with Behcet's disease and healthy controls. CONCLUSION: The stimulation of peripheral blood mononuclear cells with herpes simplex virus type 1 leads to the reduction of interferon-gamma producing T cells in patients with Behcet's disease. These findings suggest that the stimulation with herpes simplex virus type 1 antigen may reverse the interferon-gamma dominant status of the Behcet's disease.
