A Case of Patient with Coincident Lung Cancer and Rheumatoid Arthritis Treated with Docetaxel-Cisplatin Chemotherapy.
- Author:
Son Ook CHOI
1
;
Jae Gu JUNG
;
Bok Jin HYOUNG
;
Sang Mi PARK
;
Hyun Jung JUNG
;
Bo Hyoung PARK
;
Byoung Yong SHIM
;
Wan Uk KIM
;
Hoon Kyo KIM
Author Information
1. Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea. kimhoonkyo@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Lung cancer;
Rheumatoid arthritis;
Chemotherapy;
Docetaxel
- MeSH:
Adenocarcinoma;
Ankle Joint;
Antirheumatic Agents;
Arthralgia;
Arthritis;
Arthritis, Rheumatoid*;
Cisplatin;
Drug Therapy*;
Hand;
Humans;
Hydroxychloroquine;
Lung Neoplasms*;
Lung*;
Male;
Methotrexate;
Middle Aged;
Prednisolone;
Shoulder;
Shoulder Joint;
Wrist
- From:The Journal of the Korean Rheumatism Association
2006;13(2):166-170
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 54-year-old male was admitted due to lung cancer and polyarthralgia involving wrist, hand, shoulder, and ankle joints. Five months ago, he had been diagnosed as adenocarcinoma of the lung, and treated with three cycles of chemotherapy using gemcitabine and cisplatin. In the course of chemotherapy, he had complained symmetrical polyarthralgia of hand and shoulder joints, resembling rheumatoid arthritis (RA). After treatment with chemotherapeutic agents, he still had severe polyarthritis refractory to anti-rheumatic drugs, including prednisolone, hydroxychloroquine, and methotrexate, and thus referred to our hospital. We changed the previous anti-cancer regimens to cisplatin plus docetaxel, a semisyntheic taxane molecule, which is known to suppress experimental polyarthritis. With additional three cycles of cisplatin plus docetaxel, RA disease activity as well as polyarthralgia was nearly completely resolved, and the extent of lung cancer was not aggravated. Although RA patients have an increased risk of malignancy, the outbreak of RA was very rare in lung cancer patients. Here we report a case of coincident lung cancer and rheumatoid arthritis, which was successfully treated by docetaxel plus cisplatin chemotherapy.
