Cord Blood Cellular Proliferative Response as a Predictive Factor for Atopic Dermatitis at 12 Months.
10.3346/jkms.2012.27.11.1320
- Author:
Hyo Bin KIM
1
;
Kang Mo AHN
;
Kyung Won KIM
;
Youn Ho SHIN
;
Jinho YU
;
Ju Hee SEO
;
Hyung Young KIM
;
Ji Won KWON
;
Byoung Ju KIM
;
Ja Young KWON
;
Suk Joo CHOI
;
Kyung Ju LEE
;
Hee Jin PARK
;
Hye Sung WON
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Atopic Dermatitis;
Cohort;
Cord Blood;
Cellular Proliferative Response;
Cytokine;
Risk Factor
- MeSH:
Adult;
Cell Proliferation;
Cesarean Section;
Dermatitis, Atopic/*diagnosis/metabolism;
Female;
Fetal Blood/*cytology/metabolism;
Humans;
Infant;
Interferon-gamma/metabolism;
Interleukin-13/metabolism;
Leukocytes, Mononuclear/drug effects/*metabolism;
Male;
Odds Ratio;
Ovalbumin/toxicity;
Phytohemagglutinins/toxicity;
Predictive Value of Tests;
Pregnancy;
Risk Factors;
Sex Factors
- From:Journal of Korean Medical Science
2012;27(11):1320-1326
- CountryRepublic of Korea
- Language:English
-
Abstract:
Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-gamma, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months.
