Determinants of Brachial-Ankle Pulse Wave Velocity in Normotensive Young Adults with Type 2 Diabetes Mellitus.
10.3346/jkms.2012.27.11.1359
- Author:
Bo Gwang CHOI
1
;
Ji Hyun KANG
;
Yun Kyung JEON
;
Sang Soo KIM
;
Chang Won LEE
;
In Joo KIM
;
Yong Ki KIM
;
Bo Hyun KIM
Author Information
1. Kim Yong Ki Internal Medicine Clinic, Busan, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Pulse Wave Velocity;
Type 2 Diabetes;
Normotension
- MeSH:
Adult;
Alanine Transaminase/blood;
Ankle/*physiology;
Aspartate Aminotransferases/blood;
Blood Pressure/physiology;
Brachial Artery/*physiology;
C-Peptide/analysis;
Diabetes Mellitus, Type 2/*physiopathology;
Female;
Heart Rate/physiology;
Hemoglobin A, Glycosylated/analysis;
Humans;
Lipids/analysis;
Male;
Pulse Wave Analysis;
Questionnaires;
Retrospective Studies;
Sex Factors;
gamma-Glutamyltransferase/blood
- From:Journal of Korean Medical Science
2012;27(11):1359-1363
- CountryRepublic of Korea
- Language:English
-
Abstract:
Brachial-ankle pulse wave velocity (baPWV) is simple, noninvasive method which correlates well with arterial stiffness. Herein, we assessed the determinants of baPWV in normotensive young adults with type 2 diabetes. We retrospectively enrolled 103 consecutive type 2 diabetic patients aged between 30 and 39 yr who measured baPWV with noninvasive pulse wave analyzer. The anthropometric parameters, blood pressure, pulse rate, fasting plasma glucose, fasting insulin, fasting C-peptide, HbA1c, lipid profile, hs-CRP, albuminuria status, AST/ALT, gamma-GTP were checked concurrently. Also, we investigated history of smoking, alcohol drinking and medications by questionnaire. We found that maximal baPWV was positively correlated with mean blood pressure (r = 0.404, P < 0.001), heart rate (r = 0.285, P = 0.004), AST (r = 0.409, P < 0.001), ALT (r = 0.329, P = 0.001), gamma-GTP (r = 0.273, P = 0.006), Urine albumin/creatinine ratio (r = 0.321, P = 0.003). By multiple linear regression, mean blood pressure and heart rate were significantly associated with maximal baPWV in male and total group. In female group, mean blood pressure was the only variable associated with maximal baPWV. These factors can be surrogate markers of arterial stiffness in this population.
