A Case of Coumarin-Induced Skin Necrosis.
- Author:
Sang Hee HAM
1
;
Hoon KANG
;
Young Min PARK
;
Sang Hyun CHO
Author Information
1. Department of Dermatology, College of Medicine, The Catholoic University of Korea, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Coumarin;
Skin necrosis
- MeSH:
Administration, Oral;
Aged;
Blood Vessels;
Breast;
Buttocks;
Female;
Hemorrhage;
Humans;
Necrosis*;
Rupture;
Skin*;
Thrombosis
- From:Korean Journal of Dermatology
2000;38(8):1133-1135
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Coumarin-induced skin necrosis is a rare complication of oral administration of coumarin derivatives. Clinically, the lesions begin with well-defined purpuric patches and progress to bullae and necrosis on the trunk, buttock or female breast. Histopathologic findings show a fibrinoid degeneration or thrombus formation in the dermal blood vessels with occasional vessel rupture and hemorrhage. We report a 77-year-old man who suffered from a typical necrotic patch on his right buttock developing during the course of coumarin therapy. Our case was diagnosed as coumarin-induced skin necrosis, based on the characteristic clinical course and histopathologic findings.
