Cyclooxygenase-2 Expression and Angiogenesis in Invasive Cervical Cancer.
- Author:
Bong Sik MIN
1
;
Woo Seok SOHN
;
Kee Taek JANG
;
Sung Won LEE
;
Hong Bai KIM
;
Yong Woo LEE
;
Sung Won KANG
;
Yang Suh PARK
;
Pong Rheem JANG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Korea.
- Publication Type:Original Article
- Keywords:
Cyclooxygenase-2;
Angiogenesis;
Cervical cancer
- MeSH:
Carcinogenesis;
Cyclooxygenase 2*;
Humans;
Microvessels;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
2002;45(3):399-403
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumor growth and angiogenesis of gastrointestinal and other cancers. This was the study to determine the relationship between tumor vascularity and COX-2 expression in invasive cervical cancer. METHODS: We examined the expression of COX-2 and microvessel density (MVD) by immunohis- tochemical staining in 21 specimens collected from invasive cervical cancer patients. RESULTS: All specimens showed weak and strong immunoreactivity, with 52.4% strong reactivity. Microvessel count was higher (median 136) in the strong COX-2 immunoreactivity specimens than the weaks (median 90), and MVD was significantly correlated with the COX-2 immunoreactivity (P=0.002). CONCLUSION: These preliminary data indicate that overexpression of COX-2 may play an important role in carcinogenesis of cervical cancer and this could be partially attributable to modulation of angiogenesis by COX-2. COX-2 maybe a target for future research in the tumorigenesis of the invasive cervical cancer.
