Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report.
10.3350/cmh.2015.21.2.180
- Author:
Sung Gyu IM
1
;
Sun Hong YOO
;
Young Min PARK
;
Sang Jin LEE
;
Sun Kyung JANG
;
Dong Ok JEON
;
Hyo Jin CHO
;
Mi Jung OH
Author Information
1. Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea. calla0108@catholic.ac.kr
- Publication Type:Case Reports
- Keywords:
Lamotrigine;
Hypersensitivity;
Hepatotoxicity
- MeSH:
Adult;
Alanine Transaminase/blood;
Anticonvulsants/*adverse effects/therapeutic use;
Aspartate Aminotransferases/blood;
Drug Hypersensitivity/complications/*diagnosis;
Humans;
Liver/enzymology/metabolism;
Liver Failure/*etiology;
Male;
Stevens-Johnson Syndrome/diagnosis/drug therapy;
Triazines/*adverse effects/therapeutic use
- From:Clinical and Molecular Hepatology
2015;21(2):180-182
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33-year-old male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine.
