Diagnosis and management of amyotrophic lateral sclerosis.
10.5124/jkma.2015.58.2.131
- Author:
Je Young SHIN
1
;
Kwang Woo LEE
Author Information
1. Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. kwoo@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Amyotrophic lateral sclerosis;
Epidemiology;
Pathophysiology;
Diagnosis;
Therapeutics
- MeSH:
Amyotrophic Lateral Sclerosis*;
Diagnosis*;
Electromyography;
Epidemiology;
Genetics;
Motor Neurons;
Neurodegenerative Diseases;
Neurologic Examination
- From:Journal of the Korean Medical Association
2015;58(2):131-138
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons. The clinical diagnosis is confirmed by careful history taking, neurologic examination and electromyography. Like other neurodegenerative disease, ALS has many genetic and environmental factors. There are many studies reported about the pathogenesis and treatment of ALS. Many clinical trials are currently in progress. Herein we review about the epidemiology, genetics, pathophysiology, diagnosis and treatment of ALS.
