Expression of Proliferating Cell Nuclear Antigen (PCNA) of Major Intrahepatic Bile Duct Epithelium in Resected Liver Tissue with Hepatolithiasis and Hepatolithiasis Associated with Cholangiocarcinoma.
- Author:
Shi Nae LEE
1
;
Sun Hee SUNG
;
Woon Sup HAN
Author Information
1. Department of Pathology, Ewha Womans University College of Medicine, Seoul, Korea. woonshan@shinbiro.com
- Publication Type:Original Article
- Keywords:
Proliferating Cell Nuclear Antigen-Bile Duct Diseases-Cholangiocarcinoma
- MeSH:
Bile Ducts;
Bile Ducts, Intrahepatic*;
Cell Proliferation;
Cholangiocarcinoma*;
Epithelium*;
Hyperplasia;
Liver*;
Proliferating Cell Nuclear Antigen*
- From:Korean Journal of Pathology
2002;36(4):232-237
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Histologic progressive changes of bile duct epithelium with hyperplasia, dysplasia and cholangiocarcinoma could be caused by hepatolithiasis. To be clarified as a neoplastic process, this histologic process should be evaluated with various aspects of cell biology. METHODS: Immunohistochemical study of proliferating cell nuclear antigen (PCNA) was performed on 45 cases (10; normal, 15; hyperplasia, 14; low-grade dysplasia:LGD, 6; high-grade dysplasia: HGD) of hepatolithiasis and 10 cases (all HGD) of hepatolithiasis with cholangiocarcinoma. RESULTS: In the hepatolithiasis, mean PCNA labelling indices (LI) of normal, hyperplasia, LGD and HGD of major intrahepatic bile duct epithelium were 24.5+/-4.3, 51.5+/-0.1, 62.0+/-.4 and 84.7+/-.3, respectively and gradually increased. Mean LI of PCNA in HGD of major intrahepatic bile duct epithelium of hepatolithiasis with cholangiocarcinoma was 68.7+/-.7, which was similar to that of LGD in hepatolithiasis without cholangiocarcinoma. CONCLUSIONS: Histologic transformation through hyperplasia, dysplasia and carcinoma in major intrahepatic bile duct epithelium of hepatolithiasis may be a neoplastic process if these histologic changes are evaluated in the cellular proliferation aspect.
