Ki 67 Expression and Its Correlation with the Proliferative Index Measured by Flow Cytometry in Breast Carcinoma.
- Author:
Ji Ho PARK
1
;
Sehwan HAN
;
Byung No BAE
;
Gi Whan KIM
;
Hong Joo KIM
;
Young Duck KIM
;
Hong Young KIM
Author Information
1. Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Breast cancer;
Flow cytometry;
S-phase;
Ki 67
- MeSH:
Aneuploidy;
Breast Neoplasms*;
Breast*;
DNA;
Estrogens;
Flow Cytometry*
- From:Journal of the Korean Surgical Society
2000;59(6):720-728
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of the present study was to evaluate the clinical utility of Ki 67 labelling index and proliferative indices measured by flow cytometry in breast carcinomas. METHODS: We conducted immunohistochemical assay for Ki 67 and analyzed the DNA content and S-phase fraction by flow cytometry in 113 cases of primary breast carcinomas. Relationship between proliferative indices measured by two method and clinical biological parameters was also analyzed. RESULTS: Ki 67 labelling index than average was increased in 53 tumors (46.9%) and demonstrated a significant correlation with S-phase fraction. Higher Ki 67 labelling index was found in 28 (59.6%) of 47 tumors with high S-phase fraction whereas it was found in only 8 tumors (30.8%) with low S-phase fraction. Concordance between Ki 67 labelling index and S-phase fraction was 63.1% (p=0.017). Tumor with high S-phase fraction had a tendency to have an aneuploid. Ki 67 labelling index correlated significantly with histologic grade (p=0.001) and nuclear grade (p=0.001). An inverse correlation was found between Ki 67 and estrogen receptor expression (p=0.004). CONCLUSION: Ki 67 labelling index significantly correlated with S-phase fraction measured by flow cytometry. Ki 67 labelling index seems to be a clinically useful method because it is rapid, practical and easily performed by immunohistchemical assay.
