The Expression of bFGF m-RNA in Gastric Cancer Tissues.
- Author:
Young Woo KIM
1
;
Ho Seong HAN
;
Jin Pok KIM
Author Information
1. Department of Surgery, College of Medicine, Seoul National University.
- Publication Type:Original Article
- Keywords:
Gastric cancer;
Basic fibroblast growth factor;
In-situ hybridization;
mRNA
- MeSH:
Fibroblast Growth Factor 2;
Humans;
RNA, Messenger;
Stomach Neoplasms*
- From:Journal of the Korean Surgical Society
2000;59(6):746-750
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The production of basic fibroblast growth factor (bFGF) which is known to have a strong angiogenic activity in gastric cancer, was evaluated. METHODS: Using alkaline phosphoatase - labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated in 9 fresh advanced gastric cancer tissues by using in-situ hybridization. RESULTS: In-situ hybridization of bFGF mRNA showed a positive reaction in 8 of 9 patients. CONCLUSION: Basic fibroblast growth factor is expressed in 88% of gastric cancer tissues. In view of the profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.
