Effect of High Dose Intravenous Immunoglobulins on the Treatment of Antibody Mediated Humoral Rejection and BK Virus Infection in Renal Transplant Recipients.
- Author:
Jae Sung LEE
1
;
Jin Seok JEON
;
Dong Cheol HAN
;
Dan SONG
;
Chul MOON
Author Information
1. Department of Internal Medicine, Soonchunhyang University School of Medicine, Seoul, Korea. jeonjs@hosp.sch.ac.kr
- Publication Type:Case Report
- Keywords:
IVIG;
Acute rejection;
Kidney transplantation
- MeSH:
Antibodies;
BK Virus*;
Communicable Diseases;
Humans;
Immunoglobulins;
Immunoglobulins, Intravenous*;
Immunosuppression;
Kidney Transplantation;
Plasmapheresis;
Prognosis;
Rituximab;
Transplantation*
- From:The Journal of the Korean Society for Transplantation
2007;21(1):140-142
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Despite the recent advances in immunosuppression, antibody mediated acute rejection is associated with a poor prognosis. Therapeutic interventions such as polyclonal antibodies, rituximab, and plasmapheresis have been used for the treatment of antibody mediated rejection. However, these treatments are associated with a serious infectious complication. Recently, Intravenous immunoglobulin (IVIG) are known to have powerful immunomodulatory effects on inflammatory and infectious disease. We successfully rescued two patients who had concomitant antibody mediated rejection and BK virus infection. IVIG could be a preferable choice for treatment of humoral rejection in the presence of infection.
