Ketamine anaesthesia following premedication of rabbits with vitamin C.
- Author:
Abdullahi ELSA
1
;
Stephen UBANDAWAKI
Author Information
1. Department of Veterinary Medicine and Surgery, Usmanu Danfodiyo University, Sokoto, Nigeria. atelsa2002@yahoo.com.
- Publication Type:Original Article
- Keywords:
ketamine;
rabbits;
vitamin C
- MeSH:
Anesthesia/*veterinary;
Anesthesia, General/*veterinary;
*Anesthetics, Dissociative;
Animals;
Ascorbic Acid/*therapeutic use;
Bicarbonates/blood;
Blood Glucose/drug effects;
Body Temperature/drug effects;
Calcium/blood;
Dose-Response Relationship, Drug;
Female;
Heart Rate/drug effects;
*Ketamine;
Male;
Oxygen/blood;
Premedication/*veterinary;
*Rabbits;
Respiration/drug effects
- From:Journal of Veterinary Science
2005;6(3):239-241
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effects of vitamin C on ketamine anesthesia was studied. In normal rabbits the onset and duration of ketamine induced anesthesia were 6.0+/-0.5 and 36.0+/-0.9 min, respectively. Pre-treatment of rabbits with 30, 60 and 240 mg/kg, i.m. of vitamin C followed by ketamine 40 mg/ kg i.m. resulted in significant (p<0.05)decrease in the onset and increase in duration of ketamine anesthesia to 5.0 +/-0.06 and 37.0+/-0.7;4.0 +/-0.5 and 39.0*0.6;2.0+/-2.3 and 44.0+/-0.8 min, respectively. There was also significant (p<0.05)decrease in the heart rates in the animals treated with vitamin C and ketamine combinations. Serum analysis showed a significant (p<0.05)increase in blood glucose. The observed decreased in serum calcium and phosphorous following ketamine injection was prevented by pretreatment with vitamin C. These results suggest that vitamin C at higher doses could potentiate ketamine anesthesia in rabbits.
