Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen.
- Author:
Byoung Sun CHANG
1
;
Gregory A BOHACH
;
Sang Un LEE
;
William C DAVIS
;
Lawrence K FOX
;
Witold A FERENS
;
Keun Seok SEO
;
Hye Cheong KOO
;
Nam Hoon KWON
;
Yong Ho PARK
Author Information
1. Animal Health Research, LG Life Sciences Ltd., Daejeon 305-380, Korea.
- Publication Type:Brief communication ; Research Support, Non-U.S. Gov't
- Keywords:
bovine mastitis;
CD4 + CD25 + T regulatory cells;
immunosuppression;
Staphylococcus aureus;
superantigens
- MeSH:
Animals;
Cattle;
Cell Proliferation;
Female;
Lymphocyte Activation/immunology;
Mastitis, Bovine/*immunology/microbiology;
Staphylococcal Infections/immunology/*veterinary;
Staphylococcus/*immunology;
*Superantigens;
T-Lymphocytes/*immunology
- From:Journal of Veterinary Science
2005;6(3):247-250
- CountryRepublic of Korea
- Language:English
-
Abstract:
Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4+:CD8+ T cell ratio and induction of CD8+T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus). The increase of activated CD8+(ACT2+ BoCD8+) T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8+ T cells (CD8+ CD26+)and well-established human CD4+ CD25+ T regulatory (Tr)cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.
