The Effects of Lidocaine and Propranolol on Heart Rate and Blood Pressure of the Ketamine.
10.4097/kjae.1986.19.6.530
- Author:
Hun CHEONG
1
;
Sung Su CHUNG
;
Woong Mo IM
Author Information
1. Department of Anesthesiology, Chonnam University Medical School, Kwang Ju, Korea.
- Publication Type:Original Article
- MeSH:
Autonomic Nervous System;
Blood Pressure*;
Heart Rate*;
Heart*;
Humans;
Ketamine*;
Lidocaine*;
Propranolol*
- From:Korean Journal of Anesthesiology
1986;19(6):530-536
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is well known that ketamine produces an increase in the heart rate and blood pressure. Lidocaine has a direct myocardial depressant effect with indirect stimulant effects mediated by the autonomic nervous system, and propranolol, beta-adrenergic receptor blockade, has negative chronotropic effects through the beta-adrenergic blockade. In order to investigate the effect of propranolol and lidocaine on the heart rate and blood pressure increased by ketamine, lidocaine, and/or propranolol were administered intravenously in awake patients. The results were as follows. 1) In ketamine(2 mg/kg) receiving group, the heart rate increased 16-19 beats per minute and systolic, diastolic and the mean blood pressure increased significantly. 2) In ketamine(2 mg/kg)-lidocaine(2 mg/kg) receiving group, the heart rate increased l2-14 beats per minute, and the systolic, diastolic and mean blood pressure increased significantly. 3) In ketamine(2 mg/kg)-propranolol(0.02 mg/kg) receiving group, the heart rate increased below 5 beats per minute and systolic, diastolic, and the mean blood pressure increased significantly. 4) In ketamine(2 mg/kg)-propranolol(0.02 mg/kg)-lidocaine(2 mg/kg) receiving group, the heart rate increased only 3-4 beats per minute and systolic, diastolic, and mean pressures increased significantly. From the above results, the chronotropic effect of ketamine was markedly attenuated by propranolol or propranolol-lidocaine but not attenuated by lidocaine, and the pressor effect was not attenuated by lidocaine, or propranolol and propranolol with lidocaine.
