Inhibition of IgE-mediated anaphylactic reaction by Mentha arvensis in rats.
- Author:
Yong Gil CHOI
1
;
Sang Hyun KIM
;
Dae Keun KIM
;
Dong Ok EOM
;
Byeong Suk CHAE
;
Tae Yong SHIN
Author Information
1. College of Pharmacy, College of Science, Woosuk University, Chonju, Chonbuk, South Korea.
- Publication Type:Original Article
- Keywords:
Mentha arvensis;
anaphylactic reaction;
TNF-alpha;
anti-dinitrophenyl IgE;
mast cells
- MeSH:
Anaphylaxis*;
Animals;
Histamine Release;
Immunoglobulin E;
Immunoglobulins;
Mast Cells;
Mentha*;
Passive Cutaneous Anaphylaxis;
Rats*;
Tumor Necrosis Factor-alpha;
Water
- From:Journal of Asthma, Allergy and Clinical Immunology
2000;20(4):601-608
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It has been reported that Mentha arvensis water extract (MAWE) inhibited systemic anaphylaxis and histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. OBJECTIVE AND METHOD: This study was undertaken to determine the inhibitory effects of immunoglobulin E (IgE)-mediated anaphylactic reaction by MAWE. This paper deals with an evaluation of the effect of MAWE on the anti-dinitrophenyl (DNP) IgE antibody induced anaphylactic reaction in rats. We also investigated the influence of MAWE on anti-DNP IgE antibody-induced tumor necrosis factor-alpha (TNF-alpha) production. RESULTS: MAWE inhibited passive cutaneous anaphylaxis (PCA) when intravenously, intrap- eritoneally, and orally administered. MAWE dose-dependently inhibited histamine release from RPMC activated by anti-DNP IgE antibody. Moreover, MAWE had an inhibitory effect on anti-DNP IgE antibody induced TNF-alphaproduction from RPMC. CONCLUSION: These results suggest that MAWE inhibits the IgE-mediated anaphylactic reaction in rats.
