5 Cases of Granulosa Cell Tumors of the Ovary.
- Author:
Hea Ryon JUNG
1
;
Seung Kwon KOH
;
Jee Young HAN
;
Eun Seop SONG
;
Jee Huyn PARK
;
Keon Young LEE
;
Sung Ook HWANG
;
Moon Whan IM
;
Byoung Ick LEE
;
Woo Young LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Inha University, Incheon, Korea.
- Publication Type:Case Report
- Keywords:
Juvenile granulosa cell tumor;
Adult granulosa cell tumor;
Sex-cord stromal tumor
- MeSH:
Adult;
Diagnosis;
Estradiol;
Estrogens;
Female;
Granulosa Cell Tumor*;
Granulosa Cells*;
Humans;
Inhibins;
Ovary*;
Physical Examination;
Sex Cord-Gonadal Stromal Tumors;
Biomarkers, Tumor;
Uterine Hemorrhage
- From:Korean Journal of Obstetrics and Gynecology
2004;47(1):212-219
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sex cord stromal tumors (GCT) of the ovary compose just 5% of ovarian tumors. Most of them are granulosa cell tumors (GCT). There are two types of tumors, juvenile (JGCT) and adult type (AGCT), which have different clinical and histopathological features. JGCT represents only 5% of GCT. GCT is characterized by secretion of estrogen. Patients may present with vaginal bleeding in adult type, and sexual pseudoprecocity in juvenile type, as results of prolonged exposure to tumor-derived estrogen. Surgery is a principle of treatment and required for definite tissue diagnosis, staging, and tumor debulking. Survival of patients with GCT is generally excellent because most patients present with early stage disease. Because of the propensity of GCT to recur years after initial diagnosis, prolonged surveillance such as physical examination and serum tumor markers such as estradiol and inhibin is reasonable. We present 5 cases GCT, 4 AGCT and 1 JGCT, with brief review of literature.
