Unusual Presentation of Large B Cell Lymphoma- Bone and Stomach- Treated with Autologous Transplantation.
- Author:
Bokyung KIM
1
;
Sung Yong OH
;
Suee LEE
;
Hyuk Chan KWON
;
Sung Hyun KIM
;
Sook Hee HONG
;
Sung Soo KIM
;
Hyo Jin KIM
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. kimhj@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Extranodal;
Diffuse large B-cell lymphoma;
Stomach;
Bone
- MeSH:
Autografts*;
Drug Therapy;
Femur;
Gastrointestinal Tract;
Hematemesis;
Humans;
Knee Joint;
Liver;
Lymphoma, B-Cell;
Peripheral Blood Stem Cell Transplantation;
Stomach;
Testis;
Transplantation, Autologous*
- From:Cancer Research and Treatment
2007;39(4):181-184
- CountryRepublic of Korea
- Language:English
-
Abstract:
Extranodal presentation of diffuse large B cell lymphoma (DLBL) is frequently observed in the gastrointestinal tract, CNS, bone, testes and liver. However, the simultaneous detection of multiple extranodal involvement at presentation is quite an uncommon occurrence. In this study, we report on a patient with an uncommon presentation of DLBL, and he had symptoms of left knee joint pain and hematemesis, characterized by bone and stomach involvement. Computed tomography and fluorodeoxyglucose-positron emission tomography (FDG-PET) scanning revealed a rapid, extensive spread to the bones and soft tissues. Subsequent histopathological examination verified the bony and gastric CD20-positive DLBL localization. We diagnosed this case as DLBL of stage IV with an international prognostic index of 3, and classified him into the high intermediate risk group. This patient was treated via chemotherapy with an R-CHOP regimen. After achieving a partial response, the patient received autologous peripheral blood stem cell transplantation. The patient attained partial remission, as shown on the FDG-PET scan, and he displayed improvement of his left femur pain.
