Effect of Some Immunosuppressive Agents on the Survival of Experimental Skin Homografts in Rats.
- Author:
Won Suk KIM
- Publication Type:Original Article
- MeSH:
Allografts*;
Animals;
Azathioprine;
Immunosuppressive Agents*;
Lymphocytes;
Lymphoid Tissue;
Prednisolone;
Rats*;
Skin*;
Spleen;
Transplants
- From:Korean Journal of Dermatology
1970;8(2):23-29
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-rat lymphocyte rabbit serum was prepared with lymphoid tissue of rat spleen. Prednisolone, Imuran and this antiserum were used to prolong the survival of full-thickness sliin homograft in albino rats. The results were as follows. l. Administratio of tle anti-rat lymphocyte rabbit serum in a dose of 0. 3cc for 2 days before grafting and 0. 3cc every 3 days until rejection resulted in prolongation of the, urvival of the grafts. (Mean, 15.3 days) 2. Administration of preInisolone to the recipients in a dose of 2mg/kg/day from 7 days Iielore grafting to the time of rejection resulted in prolongation of survival of the, rafts. (Mean, 8.4 days) 3. Adminitration of Imuran to the reciipients in a dose of 5mg/kg/day from 7 day defore gvafting to the time cif rejection resulted in prolongation of the survival of ther afts. (Mean,14.6 days)
