Long Menstrual Cycle Is Associated with Type 2 Diabetes Mellitus in Korean Women.
10.4093/dmj.2011.35.4.384
- Author:
Unjin SHIM
1
;
Jee Young OH
;
Hye Jin LEE
;
Young Sun HONG
;
Yeon Ah SUNG
Author Information
1. Division of Endocrinology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. jyoh@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Obesity;
Oligomenorrhea
- MeSH:
Ambulatory Care Facilities;
Blood Pressure;
Body Mass Index;
Cardiovascular Diseases;
Cholesterol;
Cholesterol, HDL;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Female;
Glucose;
Humans;
Lipoproteins;
Menstrual Cycle;
Obesity;
Oligomenorrhea;
Risk Factors;
Triglycerides
- From:Diabetes & Metabolism Journal
2011;35(4):384-389
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Long menstrual cycle is a risk factor for developing type 2 diabetes and cardiovascular disease in women. We aimed to evaluate the association between existing type 2 diabetes and oligomenorrhea before diagnosis of diabetes, and to observe the differences in this association among obese and non-obese Korean women. METHODS: Patients with type 2 diabetes (n=118) and without any clinical evidence of abnormal glucose regulation (n=258) who attended the outpatient clinic of a university hospital and were over age 30. Patients self-reporting a menstrual cycle over 40 days during their 20s were defined as oligomenorrhea before diagnosis of diabetes. Obesity was defined as having a body mass index (BMI) over 25 kg/m2. RESULTS: The frequency of oligomenorrhea before diagnosis of diabetes was almost two-fold higher in women with type 2 diabetes than in the control group (16.1% vs. 8.5%, P=0.03). Oligomenorrhea was associated with type 2 diabetes after adjusting for age, BMI, systolic blood pressure, triglycerides, and high density lipoprotein cholesterol (odds ratio, 3.89; 95% confidence interval, 1.37 to 11.04). Among women with oligomenorrhea before diagnosis of diabetes, the frequency of type 2 diabetes was significantly higher in obese subjects than in their non-obese counterparts (90.9% vs. 30.0%, P=0.03). CONCLUSION: Having a long menstrual cycle could be a risk factor for the development of type 2 diabetes, especially in obese women.