Effects of Sinapic Acid of 4 Vessel Occlusion Model-Induced Ischemia and Cognitive Impairments in the Rat.
- Author:
Young Ock KIM
1
;
Sang Won LEE
;
Myung Sook OH
;
Hee Jae LEE
Author Information
1. Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong, Korea.
- Publication Type:Original Article
- Keywords:
Sinapic acid;
Neuroprotection effect;
Memory;
Hippocampus
- MeSH:
Animals;
Brain Ischemia;
Coumaric Acids;
Glycosaminoglycans;
Hippocampus;
Ischemia;
Maze Learning;
Memory;
Neurons;
Neuroprotective Agents;
Rats;
Receptors, GABA-A
- From:Clinical Psychopharmacology and Neuroscience
2011;9(2):86-90
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model. METHODS: MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed. RESULTS: In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated. CONCLUSION: The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons.
