Two Cases of Miller Fisher Syndrome without Ataxia.
- Author:
Mi JU
1
;
Kye Hyang LEE
;
Sook Young KIM
Author Information
1. Department of Pediatrics, Catholic University of Daegu, School of Medicine, Daegu, Korea. rosalia@cu.ac.kr
- Publication Type:Case Report
- Keywords:
Miller Fisher syndrome;
Anti-GQ1b antibody
- MeSH:
Ataxia*;
Clinical Laboratory Techniques;
Diagnosis;
Herpesvirus 4, Human;
Immunoglobulin G;
Immunoglobulins;
Miller Fisher Syndrome*;
Ophthalmoplegia
- From:
Journal of the Korean Child Neurology Society
2007;15(2):205-210
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A classic triad of acute external ophthalmoplegia, areflexia and ataxia characterizes Miller Fisher syndrome(MFS). Diagnosis is based on clinical findings and supported by two laboratory findings; CSF albuminocytological dissociation and serum anti-GQ1b IgG antibody testing. Anti-GQ1b antibody is a key factor in the pathogenesis of Miller Fisher syndrome and a useful marker in laboratory diagnosis. Here we report 2 cases with Miller Fisher syndrome without ataxia, whose major symptom was acute external ophthalmoplegia. Case 1 was associated with preceding Epstein-Barr virus infection and negative anti- GQ1b antibody. Case 2 was positive for the anti-GQ1b antibody. Both received intravenous immunoglobulin and fully recovered within 2 months after the onset of disease.