F18-fluorodeoxyglucose-positron emission tomography and computed tomography is not accurate in preoperative staging of gastric cancer.
10.4174/jkss.2011.81.2.104
- Author:
Tae Kyung HA
1
;
Yun Young CHOI
;
Soon Young SONG
;
Sung Joon KWON
Author Information
1. Department of Surgery, Hanyang University College of Medicine, Seoul, Korea. sjkwon@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Gastric cancer;
18F-FDG-PET/CT;
MDCT;
Preoperative staging
- MeSH:
Carcinoma, Signet Ring Cell;
Endoscopy;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Retrospective Studies;
Stomach Neoplasms
- From:Journal of the Korean Surgical Society
2011;81(2):104-110
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the clinical benefits of F18-fluorodeoxyglucose-positron emission tomography and computed tomography (18F-FDG-PET/CT) over multi-detector row CT (MDCT) in preoperative staging of gastric cancer. METHODS: FDG-PET/CT and MDCT were performed on 78 patients with gastric cancer pathologically diagnosed by endoscopy. The accuracy of radiologic staging retrospectively was compared to pathologic result after curative resection. RESULTS: Primary tumors were detected in 51 (65.4%) patients with 18F-FDG-PET/CT, and 47 (60.3%) patients with MDCT. Regarding detection of lymph node metastasis, the sensitivity of FDG-PET/CT was 51.5% with an accuracy of 71.8%, whereas those of MDCT were 69.7% and 69.2%, respectively. The sensitivity of 18F-FDG-PET/CT for a primary tumor with signet ring cell carcinoma was lower than that of 18F-FDG-PET/CT for a primary tumor with non-signet ring cell carcinoma (35.3% vs. 73.8%, P < 0.01). CONCLUSION: Due to its low sensitivity, 18F-FDG-PET/CT alone shows no definite clinical benefit for prediction of lymph node metastasis in preoperative staging of gastric cancer.
