Norfloxacin Hydrogel Coated Urethral Catheters for Prevention of Catheter Associated Urinary Tract Infection in the Rabbit.
- Author:
Dong Ik KIM
1
;
Seung Ju LEE
;
Yong Hyun CHO
Author Information
1. Department of Urology, National Medical Center, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Urinary tract infections;
Urinary catheterization;
Norfloxacin;
Rabbits
- MeSH:
Bacteriuria;
Biofilms;
Catheters*;
Cross Infection;
Health Care Costs;
Hydrogel*;
Microscopy, Electron, Scanning;
Norfloxacin*;
Polyurethanes;
Rabbits;
Urinary Bladder;
Urinary Catheterization;
Urinary Catheters*;
Urinary Tract Infections*;
Urinary Tract*
- From:Korean Journal of Urology
2002;43(11):980-986
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We developed a norfloxacin hydrogel coated urethral catheters, and evaluated its efficacy in a rabbit model. Our goal was to create a catheter that would prevent the development of catheter associated nosocomial urinary tract infections. MATERIALS AND METHODS: We inserted either an untreated, a polyurethane hydrogel coated or a polyurethane hydrogel with norfloxacin coated 8Fr Foley, catheter into the bladders of New Zealand White rabbits. Urine cultures were examined daily for 7 days. Scanning electron microscopy of the catheter surface was performed to structurally analyze the biofilm. RESULTS: There was a significant improvement (p=0.002) in the average time to a positive urine culture, from 3.1 to 5.7 days, and the rate of bacteriuria of the norfloxacin coated catheters was 70% lower than that of the untreated catheters. Scanning electron microscopy showed the formation of a bacterial biofilm on the surface of the untreated catheters, but deterioration of the biofilm was visible throughout the norfloxacin hydrogel coated catheters. CONCLUSIONS: A significant benefit was realized by coating the catheter surface with a norfloxacin impregnated hydrogel. This in vivo study suggests that this procedure may provide a significant clinical advantage, and reduce health care costs, for nosocomial infections.
