Hyperlipidemia and Erection Response by Intracorporeal Injection of Papaverine.
- Author:
Young Tae KO
1
;
Sae Chul KIM
Author Information
1. Department of Urology, College of Medicine, Chung Ang University, Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Hyperlipidemia;
Erection response;
Papaverine
- MeSH:
Apoproteins;
Cholesterol;
Endothelium;
Erectile Dysfunction;
Female;
Humans;
Hypercholesterolemia;
Hyperlipidemias*;
Impotence, Vasculogenic;
Incidence;
Lipid Metabolism;
Lipoprotein(a);
Lipoproteins;
Male;
Muscle, Smooth;
Papaverine*;
Relaxation;
Risk Factors;
Triglycerides
- From:Korean Journal of Urology
1994;35(10):1113-1121
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The majority of cases of impotence are closely associated with vascular risk factors and previous studies suggested that hypercholesterolemia contributed to the vasculogenic impotence by inducing impairment of endothelium dependent relaxation of corporeal smooth muscles. However, the roles of individual parameters of lipid metabolism in the development of the vasculogenic impotence are ill defined. Herein we investigated the relationship between the erectile response induced by intracorporeal injection of papaverine and serum levels of various parameters of lipid metabolism ; total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein(a). phospholipid, apoprotein A1(ApoA1), apoprotein B(ApoB), and ratio of serum level of LDL/HDL, TC/HDL, and ApoA1/ApoB. Higher incidence of abnormal erectile response was found in patients with increased serum level of TC, LDL, ApoA1, phospholipid and increased LDL/HDL ratio, However, the erectile response to intracorporeal papaverine between the patients with abnormal parameters and those with normal levels did not show significant difference(p>0.15). These results suggest that the individual parameters of lipid metabolism by themselves may not have direct relationship with papaverine induced erectile response.
