Reduced immunoreactivities of B-type natriuretic peptide in pulmonary arterial hypertension rats after ranolazine treatment.
- Author:
Jae Chul LEE
1
;
Kwan Chang KIM
;
Soo Young CHOE
;
Young Mi HONG
Author Information
- Publication Type:Original Article
- Keywords: B-type natriuretic peptide; Heart; Pulmonary artery hypertension; Ranolazine; Right ventricles
- MeSH: Animals; Arrhythmias, Cardiac; Arterial Pressure; Death; Disease Progression; Fibrosis; Heart; Heart Ventricles; Hypertension*; Hypertrophy; Models, Animal; Myocytes, Cardiac; Natriuretic Peptide, Brain*; Pulmonary Artery; Rats*; Sodium; Vascular Diseases; Ranolazine
- From:Anatomy & Cell Biology 2016;49(1):7-14
- CountryRepublic of Korea
- Language:English
- Abstract: Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disease characterized by sustained increase in the pulmonary arterial pressure and excessive thickening and remodeling of the distal small pulmonary arteries. During disease progression, structural remodeling of the right ventricular (RV) impairs pump function, creates pro-arrhythmic substrates and triggers for arrhythmias. Notably, RV failure and lethal arrhythmias are major contributors to cardiac death in PAH that are not directly addressed by currently available therapies. Ranolazine (RAN) is an anti-anginal, anti-ischemic drug that has cardioprotective effects of heart dysfunction. RAN also has anti-arrhythmic effects due to inhibition of the late sodium current in cardiomyocytes. Therefore, we hypothesized that RAN could reduce the mal-adaptive structural remodeling of the RV, and prevent triggered ventricular arrhythmias in the monocrotaline-induced rat model of PAH. RAN reduced ventricular hypertrophy, reduced levels of B-type natriuretic peptide, and decreased the expression of fibrosis. In addition, RAN prevented cardiovascular death in rat model of PAH. These results support the notion that RAN can improve the functional properties of the RV, highlighting its potential benefits in the setting of heart impairment.
