Protective effect of rosemary on acrylamide motor neurotoxicity in spinal cord of rat offspring: postnatal follow-up study.
- Author:
Marwa A AL-GHOLAM
1
;
Hanaa Zakaria NOOH
;
Abeer E EL-MEHI
;
Abd El Moneum EL-BARBARY
;
Ahmed Zo El FOKAR
Author Information
- Publication Type:Original Article
- Keywords: Acrylamide; Motor neuron; Rosemary; Development; Spinal cord
- MeSH: Acrylamide*; Animals; Apoptosis; Female; Follow-Up Studies*; Gliosis; Humans; Models, Animal; Motor Neurons; Myelin Sheath; Rats*; Spinal Cord*
- From:Anatomy & Cell Biology 2016;49(1):34-49
- CountryRepublic of Korea
- Language:English
- Abstract: The direct interactive effects of rosemary and acrylamide on the development of motor neurons in the spinal cord remains unknown. Our goal is to confirm the protective effects of rosemary against motor neuronal degeneration induced by acrylamide in the developing postnatal rat spinal cord using a postnatal rat model. We assigned the offspring of treated female rats into control, rosemary; acrylamide group; and recovery groups. This work depended on clinical, histopathological, morphometrically, immunohistochemical and genetic methods. In the acrylamide group, we observed oxidation, motor neuron degeneration, apoptosis, myelin degeneration, neurofilament reduction, reactive gliosis. Whoever, concomitant rosemary intake and withdrawal of acrylamide modulate these effects. These findings proof that dietary rosemary can directly protect motor neuron against acrylamide toxicity in the mammalian developing spinal cord.
