Expressions of p53 and p21 in Primary Gastric Lymphomas.
10.3346/jkms.2001.16.6.731
- Author:
Jai Hyang GO
1
;
Woo Ick YANG
Author Information
1. Department of Pathology, Dankook University, College of Medicine, Cheonan, Korea. jaihyang@yahoo.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
p21;
p53;
Lymphoma;
Stomach;
Prognosis
- MeSH:
Adult;
Aged;
Antibodies, Monoclonal;
Female;
Human;
Immunohistochemistry;
Lymphoma, B-Cell/*chemistry/pathology;
Male;
Middle Age;
Peyer's Patches/chemistry/pathology;
Prognosis;
Protein p53/*analysis/immunology;
Proto-Oncogene Protein p21(ras)/*analysis/immunology;
Stomach Neoplasms/*chemistry/pathology;
Support, Non-U.S. Gov't
- From:Journal of Korean Medical Science
2001;16(6):731-735
- CountryRepublic of Korea
- Language:English
-
Abstract:
The p21 overexpression is thought to be a consequence of the p53 induced activation of the p21 gene. The immunohistochemical evaluation of p53 and p21 can be a valuable means of assessing the functional status of the p53 gene product. We examined the overexpression of p21 and p53 proteins in primary gastric lymphomas and the correlation with prognosis. A total of 32 cases of gastric lymphomas was classified into low-grade lymphomas of mucosa-associated lymphoid tissue type (n=16) and high-grade B-cell lymphomas (n=16). In low-grade lymphomas, only one case showed p53 positivity and all cases were p21-negative. In high-grade lymphomas, seven cases were p53+/p21- (44%), one case was p53+/p21+ (6%), and eight cases were p53-/p21- (50%). The p53+/p21- cases had a much lower percentage of patients sustaining a continuous complete remission state (3/7, 43%) compared with other cases (6/7, 86%). From these results, we concluded that p21 expression is rare in primary gastric lymphomas. Therefore, p53-positive lymphomas can be assumed as having p53 mutation. And combined studies of p53 and p21 may be used as a prognostic indicator in primary gastric high-grade lymphomas.
