Association between the G252A Tumor Necrosis Factor-beta Gene Polymorphism and Medication-Overuse Headache.
- Author:
Masakazu ISHII
1
;
Tomomi ONAYA
;
Hirotaka KATOH
;
Yuji KIUCHI
;
Hideyo KASAI
;
Mitsuru KAWAMURA
;
Shunichi SHIMIZU
Author Information
- Publication Type:Original Article
- Keywords: medication overuse headache; migraine; tumor necrosis factor gene
- MeSH: Alleles; Genotype; Headache; Humans; Lymphotoxin-alpha; Male; Migraine Disorders; Migraine without Aura; Tumor Necrosis Factor-alpha
- From:Journal of Clinical Neurology 2012;8(4):301-304
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND AND PURPOSE: Migraine patients are particularly prone to the complication of medication-overuse headache (MOH). Although it has been shown that A allele carriers for the tumor necrosis factor (TNF)-beta gene G252A polymorphism are at high risk of the development of migraine without aura, the relationship between the TNF-beta gene G252A polymorphism and MOH is unknown. We investigated whether the TNF-beta gene G252A polymorphism is involved in the aggravation of migraine by overuse of medications. METHODS: Forty-seven migraine patients (6 males and 41 females; age 36.4+/-10.3 years, mean+/-SD) and 22 MOH patients (1 male and 21 females; age 39.6+/-9.9 years) who had migraine were included in this study. The genotype for the TNF-beta gene G252A polymorphism was determined by polymerase-chain-reaction restriction-fragment-length polymorphism analysis. RESULTS: The distribution of TNF-beta gene G252A genotype frequency differed significantly between migraine and MOH patients (p=0.013). The G/G genotype was carried by 23% of the migraine patients but it was absent in MOH patients. CONCLUSIONS: G/G genotype carriers appear to be less susceptible to the aggravation of migraine by overuse of medications. The G252A TNF-beta gene polymorphism may be one of the factors contributing to the complications of MOH in patients with migraine.
